Kansas State (South Region, No. 4 Seed) 1 of 4 Dean WadePeter G. Aiken/Getty Images Opponent: No. 13 UC Irvine (30-5, NET: 68) Point Spread: Kansas State (-4½) The health of 6'10" sharpshooter Dean Wade was a major question mark during Kansas State's surprise run to the Elite Eight last season.
Mississippi State Bulldogs (East Region, No. 5 Seed) 2 of 4 Quinndary WeatherspoonScott Halleran/Getty Images Opponent: No. 12 Liberty (28-6, NET: 58) Point Spread: Mississippi State (-6½) The Liberty Flames have the offensive efficiency and balance to keep up with a major conference team.
Virginia Tech Hokies (East Region, No. 4 Seed) 3 of 4 Nickeil Alexander-WalkerMark Brown/Getty Images Opponent: No. 13 Saint Louis (23-12, NET: 103) Point Spread: Virginia Tech (-10½) A team that's a 10½-point favorite is on upset alert?
Wisconsin Badgers (South Region, No. 5 Seed) 4 of 4 Ethan HappDylan Buell/Getty Images Opponent: No. 12 Oregon (23-12, NET: 51) Point Spread: Wisconsin (-2) Can this one even be considered an upset at this point?
The Badgers are one of the best defensive teams in the nation, checking in at No. 3 in KenPom's defensive efficiency while holding opponents to 39.3 percent shooting (11th in NCAA) and 61.4 points per game (9th in NCAA).